Ph.D. University of California, San Francisco, 2003
Washington University in Saint Louis.
Molecular and Cellular Biology, Signal Transduction, Immunology
My research efforts focus on how cells of the immune system, specifically T cells, are activated to protect us from pathogens. T cells are vital for the establishment of protective immunity in response to vaccination and subsequent infection. Their activation requires a delicate balance between having the sensitivity to respond to low levels of pathogens, but at the same time, not respond to "self" which would lead to the development of autoimmune diseases such as lupus or rheumatoid arthritis.
In particular, I am interested in the intracellular signaling pathways that are responsible for T cell activation. This complex process involves the dynamic interplay between a multitude of signaling molecules, ultimately resulting in differentiation and proliferation. By taking a molecular and biochemical approach to dissecting the intricate pathways required for T cell activation, we hope to further understand these complicated mechanisms and determine how loss of regulation can lead to various disease states.
BIOL 321 - Molecular Biology, Cell Biology and Physiology
BIOL 325 - Molecular and Cellular Lab Techniques
BIOL 380 - Genetic Basis of Human Diseases
BIOL 383 - Virology
BIOL 480 - Immunology
BIOL 490 - Research Experience in Biology
Selected Publications & Presentations
Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, and Kumagai Y. (2019) The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications. Chem Res Toxicol. 32(3):447-455.
Goddu RN, Henderson CF, Young AK, Muradian BE, Calderon L, Bleeg LH, Fukuto JM, and Lin J. (2018) Chronic Exposure of the RAW246.7 Macrophage Cell Line to H2O2 Leads to Increased Catalase Expression. Free Radic Biol Med. 126:67-72.
Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM. (2018) The Reaction of Hydrogen Sulfide with Disulfides: Formation of a Stable Trisulfide and Implications to Biological Systems. Br J Pharmacol. 176(4):671-683.
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T. (2018) Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology. FEBS Lett. 592(12):2140-2152.
Alvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto J. (2017) The Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling. Antioxid Redox Signal. 27(10):622-633.
Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. (2016) The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation. Free Radic Biol Med. 97:136-147.
Saund, S., Sosa, V., Henriquez, S., Nguyen, Q Y., Soeda, S., Bianco, C., Millikin, R., White, C., Le, H., Ono, K., Tantillo, D., Kumagai, Y., Akaike, T., Lin, J., and Fukuto, J. (2015) The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles. Arch Biochem Biophys. 588:15-24.
Williamson, R.P., Barker, B.T., Drammeh, H., Scott, J., and Lin, J. (2014) Isolation and Genetic Analysis of an Environmental Bacteriophage: A 10-Session Laboratory Series in Molecular Virology. Biochem Mol Biol Educ. 42(6):480-5.